Clinical Study References Below are some select clinical studies on Japanese Pagoda Tree: A clinical trial of hydroxyethylrutosides in treatment of haemorrhoids of pregnancy Wijayanegara H, Mose JC, Achmad L, Sobarna R, Permadi W J Int Med Res 1992; 20(1):54-60     Double-blind, randomized clinical trial of troxerutin-carbazochrome in patients with hemorrhoids Squadrito F, Altavilla D, Oliaro Bosso S Eur Rev Med Pharmacol Sci. 2000 Jan-Apr;4(1-2):21-4.     Troxerutin in the treatment of haemorrhoids Clyne MB, Freeling P, Ginsborg S Practitioner. 1967 Mar;198(185):420-3.     Treatment of acute symptoms of hemorrhoid disease with high-dose oral O-(beta hydroxyehtyl)-rutosides Annoni F, Boccasanta P, Chiurazzi D, Mozzi E, Oberhauser V. Minerva Med. 1986; 77(37):1663-8. Below are some select clinical studies on Horse chestnut on hemorrhoids: Aescin: pharmacology, pharmacokinetics and therapeutic profile Sirtori CR Pharmacol Res. 2001 Sep;44(3):183-93.     A new non-corticoid preparation with an escin base in topical treatment of the ano-rectal varicose syndrome Nappi R Clin Ter. 1978 Aug 15;86(3):219-28.     Therapeutic activity of a new topical preparation in ano-rectal varicose pathology Malin L, Pollinzi V G Clin Med. 1978 Nov;59(11):521-9.

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